Product Spotlight for 5/5/2020: Peptides and Cancer, From A to (Nearly) Z

Utilizing peptides against cancer has been long established.1-4 It is fortunate that even with the plethora of cancers needing treatment, there are also nearly innumerable peptides that can be applied to promising therapies. New England Peptide | Peptides International has always carried a large portfolio of these, with literally hundreds available. We will run through just a few of these by categories or individual products, along with some references of associated applications that were recently published.

Antipains
Antipain Agent Shrinks Oral Cancers, Sparing Healthy Tissue5

Caspases
Caspase-1-Dependent Inflammasomes Mediate Photoreceptor Cell Death in Photo-Oxidative Damage-Induced Retinal Degeneration6

Cathepsins
Structural and Kinetic Evidence of Aging After Organophosphate Inhibition of Human Cathepsin A7

Chlorotoxin
Chlorotoxin Redirects Chimeric Antigen Receptor T Cells for Specific and Effective Targeting of Glioblastoma8

Chromatin
Single-Cell Chromatin profiling Reveals Demethylation-Dependent Metabolic Vulnerabilities of Breast Cancer Epigenome9

Clusterin
High Clusterin (CLU) mRNA Expression Levels in Tumors of Colorectal Cancer Patients Predict a Poor Prognostic Outcome10

Collagenase
A Size‐Changeable Collagenase‐Modified Nanoscavenger for Increasing Penetration and Retention of Nanomedicine in Deep Tumor Tissue11

Fibronectin-Binding Peptides
Fibronectin in the Tumor Microenvironment Activates a TLR4-dependent Inflammatory Response in Lung Cancer Cells12

Galardin
Monitoring Protease Activity in Biological Tissues Using Antibody Prodrugs as Sensing Probes13

Gastrin
Novel Gastrin-Releasing Peptide Receptor Targeted Near-Infrared Fluorescence Dye for Image-Guided Surgery of Prostate Cancer14

Gastrin-Releasing Peptide
Imaging the Distribution of Gastrin Releasing Peptide Receptors in Cancer15

Gonadotropin
A Step Forward in Identifying the Right Human Chorionic Gonadotropin Assay for Testicular Cancer16

Goserelin
Abstract P2-12-11: Does Goserelin Have an Effect on Quality of Life in Women Who Have Chemotherapy for Early Breast Cancer? Results from the OPTION Randomised Trial17

Hepcidin
Iron and Hepcidin Mediate Human Colorectal Cancer Cell Growth18

Leupeptin
Proteolytic Processing of PD-L1 by ADAM Proteases in Breast Cancer Cells19

LISA-101
Design of Fluorogenic Probes and Fluorescent‐Tagged Inhibitors for γ‐Glutamyl Cyclotransferase20

Melanocortin
Expression of Melanocortin 1 Receptor Before and After Narrowband UVB Phototherapy Treatment in Patients with Stable Vitiligo: A Prospective Study21

MMP
MicroRNA-429 Inhibits Bone Metastasis in Breast Cancer by Regulating CrkL and MMP-922

Nesfatin-1
Nesfatin‑1 is a Potential Diagnostic Biomarker for Gastric Cancer23

Neuromedin B
Neuropeptide Bombesin Receptor Activation Stimulates Growth of Lung Cancer Cells Through HER3 With a MAPK-Dependent Mechanism24

Octreotide
A Cinical Audit of Use of Octreotide in the Management of Inoperable Malignant Bowel Obstruction at a Large Cancer Centre25

PAR
Protease-Activated Receptor Signalling Initiates α5β1-Integrin-Mediated Adhesion in Non-Haematopoietic Cells26

Pepstatin A
Autophagy Promotes Immune Evasion of Pancreatic Cancer by Degrading MHC-I 27

Rapamycin
Mammalian Target of Rapamycin (mTOR) Inhibitors and Skin Cancer Risk in Nonrenal Solid Organ Transplant Recipients: Systematic Review and Meta‐Analysis28

RAS-Like Estrogen-Regulated Growth Inhibitor
miR‑532‑5p Promotes Breast Cancer Proliferation and Migration by Targeting RERG29

RGD
Targeting Integrins with Radiolabeled RGD Analogs for Radiotheranostics of Metastatic Radioactive Iodine Non-Responsive Thyroid Cancer–New Avenues in…30

Sirtuin-3
Sirtuin 3 Induces Apoptosis and Necroptosis by Regulating Mutant p53 Expression in Small‑Cell Lung Cancer31

Somatostatin
Expression of Somatostatin Receptors Subtypes (1-5) mRNA in MCF7 and MDA-MB231 Breast Cancer Human Cell Lines32 (in review)

γ-Synuclein
Chimera RNA Interference Knockdown of γ-Synuclein in Human Cortical Astrocytes Results in Mitotic Catastrophe33

TAPI
Cyclosporin A Activates Human Hepatocellular Carcinoma (HepG2 cells) Proliferation: Implication of EGFR-Mediated ERK1/2 Signaling Pathway34

TNF
Control of Cancer Progression by Extracorporeal Removal of Soluble TNF-alpha Receptors35

VEGF
Basic Fibroblast Growth Factor Blockade Enhances Lung Cancer Cell Invasion by Activating the AKT/MMP‐2/VEGF Pathway36

Other Options

ME Kit for Exosome Isolation
Need to isolate exosomes for your research? Use the ME™ Kit!

•  Specific isolation of extracellular vesicles (exosomes, microvesicles) in as little as 45 minutes.
•  No ultracentrifugation required!
•  Works for multiple sample types (plasma, urine, culture media, etc.) across several species.
•  Can be modified to fit specific needs (multiple chemistries, added to beads, etc.).
•  Comes complete with positive and negative controls.

Uses:

•  Extracellular vesicle (EV) isolation for functional studies
•  RNA isolation
•  DNA isolation
•  Protein isolation
•  miRNA isolation

Custom Peptide Synthesis
At NEP | PI, we specialize in meeting our customer’s needs and delivering the highest purity in the industry.  Hallmarks of our custom peptide synthesis services include:

  • Peptides: simple to complex peptide synthesis.
  • Scale: from mg to kg scales.
  • Tools: resins, pre-loaded resins, and protected amino acid derivatives.

Our experienced scientists will work with you to personally ensure that your compound meets your specification.  Whether the issue is purity, quantity, or time, we will see to it that you are satisfied.  You have our word on it.

Should you be interested in these, or any other cancer research peptides or proteins, please feel free to contact us.   Of course, we can always tailor a custom peptide synthesis project combining these items, or a completely unique item to your specifications.

 References

  1. doi.org/10.1093/jnci/94.11.805
  2. doi.org/10.1016/j.biopha.2018.04.025
  3. doi.org/10.1016/j.bmc.2017.06.052
  4. http://jnm.snmjournals.org/content/58/Supplement_2/3S.short
  5. https://ascopost.com/News/17432
  6. doi:10.1038/s41598-020-58849-z
  7. doi.org/10.1016/j.bcp.2020.113980
  8. doi: https://doi.org/10.1101/2020.01.24.918888
  9. doi.org/10.1101/2020.02.18.954495
  10. doi:10.1016/j.clinbiochem.2019.10.008
  11. doi.org/10.1002/adma.201906745
  12. doi: 10.7150/jca.39771
  13. doi:10.1038/s41598-020-62339-7(PDF)
  14. doi.org/10.1007/s11307-019-01354-1
  15. doi.org/10.1515/cclm-2019-0319
  16. doi: 10.1515/cclm-2019-0319
  17. doi:10.1158/1538-7445.SABCS19-P2-12-11
  18. doi.org/10.1016/j.cbi.2020.109021
  19. doi.org/10.1007/s00262-019-02437-2
  20. doi.org/10.1002/psc.2984
  21. doi.org/10.3892/etm.2020.8435
  22. doi.org/10.1016/j.bone.2019.115139
  23. doi.org/10.3892/ol.2019.11200
  24. doi.org/10.1016/j.bbamcr.2019.118625
  25. doi.org/10.1136/spcare-2020-PCC.216
  26. doi.org/10.1038/s41563-019-0580-4
  27. doi.org/10.1111/ijd.14549
  28. doi.org/10.1038/s41586-020-2229-5
  29. doi.org/10.3892/etm.2019.8186
  30. doi.org/10.1089/thy.2020.0169
  31. doi.org/10.3892/or.2019.7439
  32. doi:.org/10.21203/rs.3.rs-16966/v1(PDF)
  33. doi:10.4103/1673-5374.280329
  34. doi.org/10.1007/s00210-019-01798-w
  35. doi: 10.1200/JCO.2020.38.5
  36. doi.org/10.1111/bcpt.13290

Testimonials

"We have no reason to use any other antibody company at this point! We are very pleased with your work. We realize the difficulty in obtaining high quality phosphorylated antibodies so we desire to stick with NEP. Thank you for your work on this!"
Beth A. PhD - Florida State University