We are pleased to offer another new fluorogenic substrate for the SARS-CoV and SARS-CoV-2 Main Protease (Mpro). This substrate contains the nsp4/nsp5 cleavage sequence, GVLQ↓SG19, and works as a generic peptide substrate for several coronavirus. The main protease (Mpro), also called endopeptidase C30 or 3C-like proteinase (3CLpro), controls viral replication activities, and is a prime therapeutical target. Both substrates and inhibitors of SARS-CoV-2 Mpro are of interest.1,2,3,4
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