For Science… From Science

Mini-Spotlight: A New Fluorogenic Substrate for SARS-CoV/SARS-CoV-2 Mpro­

We are pleased to offer another new fluorogenic substrate for the SARS-CoV and SARS-CoV-2 Main Protease (Mpro).  This substrate contains the nsp4/nsp5 cleavage sequence, GVLQ↓SG19, and works as a generic peptide substrate for several coronavirus.  The main protease (Mpro­), also called endopeptidase C30 or 3C-like proteinase (3CLpro), controls viral replication activities, and is a prime therapeutical target. Both substrates and inhibitors of SARS-CoV-2 Mpro are of interest.1,2,3,4



Looking for something novel?  We can also incorporate other commercially available labels or synthesize custom SARS-Cov-2 related peptides.

Stop by to visit our regularly updated COVID-19 Information Station, which contains latest news and related products and services that we offer.


  1. C.J. Kuoet al., Biochem. Biophys. Res. Commun., 318, 862 (2004).
  2. L. Zhang, et al., Science, eabb3405 (2020). DOI: 10.1126/science.abb3405
  3. S. Jo et al., J Enzyme Inhib Med Chem, 35(1) 145 (2020).
  4. W. Rut, et al., bioRxiv, (2020). (pre-print) DOI: 10.1101/2020.03.07.981928


"We have no reason to use any other antibody company at this point! We are very pleased with your work. We realize the difficulty in obtaining high quality phosphorylated antibodies so we desire to stick with NEP. Thank you for your work on this!"
Beth A. PhD - Florida State University