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Mini-Spotlight: A New Fluorogenic Substrate for SARS-CoV/SARS-CoV-2 Mpro­

We are pleased to offer another new fluorogenic substrate for the SARS-CoV and SARS-CoV-2 Main Protease (Mpro).  This substrate contains the nsp4/nsp5 cleavage sequence, GVLQ↓SG19, and works as a generic peptide substrate for several coronavirus.  The main protease (Mpro­), also called endopeptidase C30 or 3C-like proteinase (3CLpro), controls viral replication activities, and is a prime therapeutical target. Both substrates and inhibitors of SARS-CoV-2 Mpro are of interest.1,2,3,4

Dabcyl-Lys-Thr-Ser-Ala-Val-Leu-Gln-Ser-Gly-Phe-Arg-Lys-Met-Glu(Edans)-NH2

SFS-3249-v

Looking for something novel?  We can also incorporate other commercially available labels or synthesize custom SARS-Cov-2 related peptides.

Stop by to visit our regularly updated COVID-19 Information Station, which contains latest news and related products and services that we offer.

References:

  1. C.J. Kuoet al., Biochem. Biophys. Res. Commun., 318, 862 (2004).
  2. L. Zhang, et al., Science, eabb3405 (2020). DOI: 10.1126/science.abb3405
  3. S. Jo et al., J Enzyme Inhib Med Chem, 35(1) 145 (2020).
  4. W. Rut, et al., bioRxiv, (2020). (pre-print) DOI: 10.1101/2020.03.07.981928

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Beth A. PhD - Florida State University