Mini-Spotlight: A New Fluorogenic Substrate for SARS-CoV/SARS-CoV-2 Mpro­

We are pleased to offer another new fluorogenic substrate for the SARS-CoV and SARS-CoV-2 Main Protease (Mpro).  This substrate contains the nsp4/nsp5 cleavage sequence, GVLQ↓SG19, and works as a generic peptide substrate for several coronavirus.  The main protease (Mpro­), also called endopeptidase C30 or 3C-like proteinase (3CLpro), controls viral replication activities, and is a prime therapeutical target. Both substrates and inhibitors of SARS-CoV-2 Mpro are of interest.1,2,3,4



Looking for something novel?  We can also incorporate other commercially available labels or synthesize custom SARS-Cov-2 related peptides.

Stop by to visit our regularly updated COVID-19 Information Station, which contains latest news and related products and services that we offer.


  1. C.J. Kuoet al., Biochem. Biophys. Res. Commun., 318, 862 (2004).
  2. L. Zhang, et al., Science, eabb3405 (2020). DOI: 10.1126/science.abb3405
  3. S. Jo et al., J Enzyme Inhib Med Chem, 35(1) 145 (2020).
  4. W. Rut, et al., bioRxiv, (2020). (pre-print) DOI: 10.1101/2020.03.07.981928


"NEP provides antibodies that work (when all others fail) and has advised on peptides that have taken my research to new levels. There is nothing like working with NEP in terms of the comfort and assurance of attaining quality results. They are the best!"
Steven G. PhD - NX PharmaGen